Asociación AELIP

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Equipment and facilities of the group and centre: Animal House Facilities, electron microscopy facilities, live cell imaging facilities and 3D live imaging (spinning disc), confocal,TIRF, FLIM, FCCS, 3 dimensional cell culture, proteomics service, DNA sequencing service including exome sequencing.

Hutchison group

Hutchison is Professor of Cell Biology in the School of Biological and Biomedical Sciences. He has 34 years research experience in cell culture and cell biology with a focus on the role of nuclear envelope proteins in human health and disease. He completed his PhD studies at the Institute of Neurology, University College London and was a research fellow for six years at the University of Sussex before being appointed as lecturer in the School of Life Sciences, University of Dundee. He was appointmented as Chair of Cell Biology at the University of Durham in 2000. His lab focuses on the role of nuclear lamins and lamina associated proteins in cell signalling and development, including their roles in Rb signalling, β-catenin signalling, ROS signalling, DNA damage response and adipogenesis. Recently, Hutchison was awarded a £2.2M award by BBSRC, in collaboration with Procter & Gamble and LifeTechnologies corp, to develop full thickness organotypic models of skin and ageing, to replace the use of animals in skin health product development.

Jahoda Group

Jahoda is Professor in the School of Biological and Biomedical Sciences at Durham University. He obtained his PhD from the University of Dundee, and worked as a postdoc and then assistant lecturer at the University of Grenoble, France between 1982 and 1984. He returned to Dundee University as a postdoc, where he subsequently started his own laboratory, first as a Royal Society University Research Fellow and then as a lecturer. Since 1991 he has been at Durham, and is currently co director of NESCI, North East England Stem Cell Institute. His main research topics are epithelial-mesenchymal interactions and the control of skin appendage development; human hair follicle induction; transdifferentiation and reprogramming of epithelial cells, hair follicle-derived mesenchymal stem cells; and the development of in vitro skin models.  Of his main areas of current interest is development of a separate adipose depot in skin, and the implications of this for adipose stem cells and aspects of disease.

Karakesisoglou Group

Karakesisoglou is a senior lecturer at the School of Biological and Biomedical Sciences. He has 15 years of research experience in epithelial cell biology and ageing, and has published over 27 research articles. He completed his post-doctoral training at the world-renowned skin laboratory of Professor Elaine Fuchs at the University of Chicago. There, he pioneered a novel field in cell biology of how cytoskeletal linker proteins (spectraplakins) determine skin tissue architecture and homeostasis (Karakesisoglou et al., 2000; Kodama et al., 2003). His research in Durham aims to characterize the molecular links (i.e. Linker of the Nucleoskeleton and Cytoskeleton, termed LINC complex), governing the integration of the nuclear and cytoplasmic compartments in skin cells and to elucidate their role in tissue morphogenesis and degeneration using 3D in vitro cell models and mouse genetics. Work in his laboratory established novel roles for LINC proteins in skin wound healing (Rashmi et al. Nucleus, 2012), skin thickness regulation (Luke et al. J. Cell Sci, 2008), cyto-architecture (Schneider et al. Cell. Mol. Life Sci. 2011; Lu et al. Cell. Mol. Life Sci. 2012) and key ageing signalling pathways (i.e. NF-kB, TGF-beta and Wnt; Neumann et al. J. Biol. Chem. 2010; Rashmi et al. 2012).

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